个人简介

曹胜波，男，1975年出生于湖北房县。爱游戏官网合作马竞官方（中国）有限公司教授、博士生导师、国家杰出青年基金获得者（2018）。先后入选国家百千万人才工程（2017）、教育部新世纪优秀人才（2010）。兼任教育部动物医学教学指导委员会副主任委员、中国畜牧兽医学会兽医公共卫生学分会副理事长、湖北省畜牧兽医学会秘书长等。主要从事媒介传播人兽共患病致病与免疫机制、宠物疫苗、宠物诊断试剂及治疗性抗体研发。主持承担国家重点研发计划、国家自然科学基金等课题。以通讯作者在Science Signaling、Journal of Immunology、Journal of Virology、Journal of Infectious Diseases等期刊发表SCI论文30余篇，获得湖北省科技进步一等奖1项、新兽药注册证书1项。

教育经历

1994.09 - 1998.06，爱游戏官网合作马竞官方（中国）有限公司，兽医专业毕业，农学学士
1999.09 - 2002.06，爱游戏官网合作马竞官方（中国）有限公司，预防兽医学专业毕业，农学硕士
2002.09 - 2005.06，爱游戏官网合作马竞官方（中国）有限公司，动物遗传育种与繁殖（抗病育种方向）专业毕业，农学博士

工作经历

1998.7-2002.12，爱游戏官网合作马竞官方（中国）有限公司学生政治辅导员、助教。
2003.01-2006.12，爱游戏官网合作马竞官方（中国）有限公司讲师。
2007.01-2011.12，爱游戏官网合作马竞官方（中国）有限公司副教授。
2012.01-现在，爱游戏官网合作马竞官方（中国）有限公司教授、博士生导师。

研究领域

媒介传播人兽共患病致病与免疫机制、防控技术与产品研发；宠物疫苗、诊断试剂及治疗性抗体研发。

科研成果

A著作类
1.《中国兽医手册》参编。
2.《中国猪病学》参编。
3.《兽医传染病学》参编。
B论文类
1.Yunchuan Li#, Hao Zhang#, Bibo Zhu, Usama Ashraf, Zheng Chen, Qiuping Xu, Dengyuan Zhou, Bohan Zheng, Yunfeng Song, Huanchun Chen, Jing Ye*, and Shengbo Cao*.Microarray Analysis Identifies the Potential Role of Long Non-Coding RNA in Regulating Neuroinflammation during Japanese Encephalitis Virus Infection. Frontiers in Immunology. 2017,8:1237.
2.Chong Wang, Nan Zhang, Luting Qi, Jiaolong Yuan, Ke Wang, Kunlun Wang, Sicong Ma, Haili Wang, Wenjuan Lou, Pingdong Hu, Muhammad Awais, Shengbo Cao, Zhen F. Fu and Min Cui*. Myeloid-Derived Suppressor Cells Inhibit T Follicular Helper Cell Immune Response in Japanese Encephalitis Virus Infection. Journal of Immunology. 2017,199(9):3094-3105.
3.Wen He, Zikai Zhao, Awais Anees, Yunchuan Li, Zheng Chen, Shengbo Cao, Yunfeng Song, Huanchun Chen, Jing Ye*.p21-activated Kinase 4 Signaling Promotes Japanese Encephalitis Virus mediated Inflammation in Astrocytes. Front Cell Infect Microbiol. 2017,7:271.
4.Jing Ye, Zheng Chen, Yunchuan Li, Zikai Zhao, Wen He, Ali Zohaib, Yunfeng Song, Chenglin Deng, Bo Zhang, Huanchun Chen, Shengbo Cao*. Japanese Encephalitis Virus NS5 Inhibits the Type I Interferon Production by Blocking the Nuclear Translocation of IRF3 and NF-κB. Journal of Virology, 2017, 91(8): e00039-17.
5.Shengfeng Wan#, Usama Ashraf#, Jing Ye, Xiaodong Duan, Ali Zohaib, Wentao Wang, Zheng Chen, Bibo Zhu, Yunchuan Li, Huanchun Chen, Shengbo Cao*. MicroRNA-22 negatively regulates poly(I:C)-triggered type I interferon and inflammatory cytokine production via targeting mitochondrial antiviral signaling protein (MAVS). Oncotarget. 2016, 7(47):76667-76683.
6.Jing Ye, Hao Zhang, Wen He, Bibo Zhu, Dengyuan Zhou, Zheng Chen, Usama Ashraf, Yanming Wei, Ziduo Liu, Zhen F. Fu, Huanchun Chen, Shengbo Cao*.Quantitative phosphoproteomic analysis identifies the critical role of JNK1 in neuroinflammation induced by Japanese encephalitis virus. Science Signaling, 2016,9(448):ra98.
7.Usama Ashraf , Bibo Zhu, Jing Ye, Shengfeng Wan, Yanru Nie, Zheng Chen, Xiaodong Duan , Hao Zhang, Huanchun Chen, Shengbo Cao*. microRNA-19b-3p modulates Japanese encephalitis virus-mediated inflammation via targeting RNF11.Journal of Virology,2016, 90(9):4780-95.
8.Zheng Chen#, Jing Ye, Usama Ashraf, Yunchuan Li, Siqi Wei, Shengfeng Wan, Ali Zohaib,Yunfeng Song, Huanchun Chen, Shengbo Cao*. miR-33a-5p modulates Japanese Encephalitis Virus Replication by targeting Eukaryotic Translation Elongation Factor 1A1. Journal of Virology, 2016,90(7):3722-3734.
9.Bibo Zhu, Jing Ye, Usama Ashraf, Yunchuan Li Huanchun Chen, Yunfeng Song and Shengbo Cao*. Transcriptional regulation of miR-15b by c-Rel and CREB in Japanese encephalitis virus infection. Scientific Reports,2016,6:22581.
10.Jin’e Fang, Huan Li, Dexin Kong, Shengbo Cao, Guiqing Peng, Rui Zhou, Huanchun Chen , Yunfeng Song*. Scientific Reports, 2016, 29;6:34550.
11.Hao Zhang, Jun Sun, Jing Ye, Usama Ashraf, Zheng Chen,Bibo Zhu,Wen He, Qiuping Xu, Yanming Wei,Huanchun Chen, Zhen F. Fu, Rong Liu* and Shengbo Cao*. Quantitative Label-Free Phosphoproteomics Reveals Differentially RegulatedProtein Phosphorylation Involved in West Nile Virus–Induced Host Inflammatory Response. Journal of proteome research. 2015, 14(12):5157-68.
12.Ali Zohaib, Adeel Sarfraz, Qari Muhammad Kaleem, Jing Ye, Mudassar Niaz Mugha, Muhammad Tariq Navid, Faheem Ahmed Khan, Xiaodong Duan, Bibo Zhu, Shengfeng Wan and Shengbo Cao*.The Yin and Yang of Antiviral Innate Immunity in Central Nervous System. Current Pharmaceutical Design,2016,22(6):648-55.
13.Bibo Zhu, Jing Ye, Yanru Nie, Usama Ashraf,, Ali Zohaib, Xiaodong Duan, Zhen F. Fu, Yunfeng Song, Huanchun Chen, Shengbo Cao *.MicroRNA-15b Modulates Japanese Encephalitis Virus-Mediated Inflammation via Targeting RNF125. Journal of Immunology 2015,195(5):2251-62.
14.Lu Z, Cao S, Zhou H, Hua L, Zhang S, Cao J. Mechanism of Arctigenin-Induced Specific Cytotoxicity against Human Hepatocellular Carcinoma Cell Lines: Hep G2 and SMMC7721. PLoS One. 2015, 1;10(5):e0125727.
15.Qian Dong, Qiuping Xu, Xindi Ruan, Shaomei Huang, Shengbo Cao*. Monoclonal Antibodies Against NS2B of Japanese Encephalitis Virus. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 2015,34(2):96-100.
16.Fang Li#, Yueyun Wang#, Lan Yu#, Shengbo Cao, Ke Wang, Jiaolong Yuan, Chong Wang, Kunlun Wang, Min Cui*, Zhen F. Fu. Viral Infection of the Central Nervous System and Neuroinflammation Precede Blood-Brain Barrier Disruption during Japanese Encephalitis Virus Infection. Journal of Virology. 2015,89(10):5602-14.
17.Ali Zohaib#, Xiaodong Duan#, Bibo Zhu, Jing Ye, ShengfengWan, Huanchun Chen, Xueqin Liu*, Shengbo Cao*. The Role of Ubiquitination in Regulation of Innate Immune Signaling. Current Issues in Molecular Biology. 2015,18:1-10 .
18.Usama Ashraf, Jing Ye, Xindi Ruan, Shengfeng Wan, Bibo Zhu, and Shengbo Cao* Usutu virus: an emerging flavivirus in Europe. Viruses-Basel. 2015, 7(1):219-38.
19.Yang Yang#, Ying Huang#, Clement W. Gnanadurai#, Shengbo Cao, Xueqin Liu, Min Cui*, and Zhen F. Fu*.The inability of wild-type rabies virus to activate dendritic cells is dependent on the glycoprotein and correlates with its low level of the de novo-synthesized leader RNA. Journal of Virology. 2015,89(4):2157-69.
20.Yumeng Zhang#, Huan Li#, Guiqing Peng, Yong Zhang, Xiao Gao, Shaobo Xiao, Shengbo Cao, Huanchun Chen, Yunfeng Song. Mutational analysis of the functional sites in porcine reproductive and respiratory syndrome virus nonstructural protein 10. Journal of General Virology. 2015,96(Pt 3):547-52.
21.Xiaodong Duan, Ali Zohaib, Yunchun Li, Bibo Zhu, Jing Ye, Shengfeng Wan, Qiuping Xu, Yunfeng Song, Huanchun Chen, Shengbo Cao*. miR-206 modulates lipopolysaccharide-mediated inflammatory cytokine production in human astrocytes. Cellular Signalling.2015, 27(1) : 61-68.
22.Ali Zohaib, Muhammad Saqib**, Muhammad Hammad Hussain, Steeve Lowenski, Sylvie Lecollinet, Cécile Beck, Awais-ur-Rehman Sial, M. Nadeem Asi, M. Khalid Mansoor, Muhammad Saqalein, Khurram Ashfaq, Muhammad Saleem, Ghulam Muhammad and Shengbo Cao*. High Prevalence of West Nile Virus in Equines from the two provinces of Pakistan Epidemiology and Infection,2014, 31:1-5（IF2013=2.46）
23.Rong Jiang#, Jing Ye#, Bibo Zhu, Yunfeng Song, Huanchun Chen,Shengbo Cao*.Roles of TLR3 and RIG-I in Mediating the Inflammatory Response in Mouse Microglia Following Japanese Encephalitis Virus Infection. Journal of Immunology Research, 2014,2014：787023.
24.Jing Ye#, Rong Jiang#, Min Cui, Bibo Zhu, Leqiang Sun, Yueyun Wang, Ali Zohaib, Qian Dong, Xindi Ruan, Yunfeng Song, Wen He, Huanchun Chen, Shengbo Cao*. Etanercept reduces neuroinflammation and lethality in mouse model of Japanese encephalitis. Journal of Infectious Diseases.2014, 15;210(6):875-89.
25.XiaoDan Li#, XiaoFeng Li#, HanQing Ye, ChengLin Deng, Qing Ye, Chao Shan, BaoDi Shang, LinLin Xu, ShiHua Li, Shengbo Cao, Zhiming Yuan, PeiYong Shi, ChengFeng Qin*, and Bo Zhang*. Recovery of a chemically synthesized Japanese encephalitis virus revealed two critical adaptive mutations in NS2B and NS4A. Journal of General Virology 2014, 95(4):806-15.
26.Jin’e Fang#, Leqiang Sun#, Guiqing Peng, Jia Xu, Rui Zhou, Shengbo Cao, Huanchun Chen, Yunfeng Song*. Identification of Three Antiviral Inhibitors against Japanese Encephalitis Virus from Library of Pharmacologically Active Compounds 1280. PLoS ONE, 2013, 8(11): e78425.
27.Yang Yang#, Ali Zohaib#, Gong Chen, Jing Ye, Shengbo Cao*. DC-SIGN Increase Japanese Encephalitis Virus Infection. Pakestan Vet J.2013, 33(4): 408-412.
28.Jing Ye, Zheng Chen, Bo Zhang, Huan Miu, Ali Zohaib, Qiuping Xu, Huanchun Chen*, Shengbo Cao *. Heat shock protein 70 is associated with replicase complex of Japanese encephalitis virus and positively regulates viral genome replication. Plos One,2013, 8(9):e75188.
29.Jin’e Fang, Huan Li, Guiqing Peng, Shengbo Cao, F. Fu Zhen, Huanchun Chen, Yunfeng Song∗. Methods for detecting ATP hydrolysis and nucleic acid unwinding of Japanese encephalitis virus NS3 helicase. Journal of Virological Methods. 2013;194(1-2):33-8.
30.Zai J, Mei L, Wang C, Cao S, Fu ZF, Chen H, Song Y*. N-glycosylation of the premembrane protein of Japanese encephalitis virus is critical for folding of the envelope protein and assembly of virus-like particles. Acta Virologica. 2013;57(1):27-33.
31.Rui Jin, Wandi Zhu, Shengbo Cao, Rui Chen, Hui Jin, Yang Liu, Shaobo Wang, Wei Wang* and Gengfu Xiao* Japanese encephalitis virus activates autophagy as a viral immune evasion strategy. PLoS One. 2013;8(1):e52909.
32.Xindi Ruan，Shaomei Huang, Lin Shao, Jing Ye, Zheng Chen, Huanchun Chen and Shengbo Cao*.Monoclonal antibodies against NS4B protein of Japanese encephalitis virus. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy.2013,32(6):382-385.
33.Jing Ye, Bibo Zhu, Zhen F. Fu, Huanchun Chen, Shengbo Cao*. Immune evasion strategies of flaviviruses. Vaccine, 2013,31(3) : 461–471.
34.Bibo Zhu, Jing Ye, Ping Lu, Rong Jiang, Xiaohong Yang, Zhen F Fu, Huanchun Chen, Shengbo Cao*. Induction of Antigen-Specific Immune Responses in Mice by Recombinant Baculovirus Expressing Premembrane and Envelope Proteins of West Nile Virus. Virology Journal. 2012,9:132.
35.Zheng Chen,Lin Shao, Jing Ye, Yongmao Li, Shaomei Huang, Huanchun Chen and Shengbo Cao*. Generation and characterization of the monoclonal antibodies against NS3 and NS5 proteins of Japanese encephalitis virus. Hybridoma. 2012,31(2):137-41.
36.Li Mei#, Peng Wu#, Jing Ye, Lin Shao, Shaomei Huang,Yaoming Li, Xiaohong Yang, Huanchun Chen and Shengbo Cao*. Development and Application of an Antigen Capture ELISA Assay for Diagnosis of Japanese encephalitis Virus in Swine，Human and Mosquito. Virology Journal. 2012, 9:4.

科研项目

1. 重要神经嗜性人兽共患病免疫与致病机制研究，国家重点研发计划，2016-2020，项目主持
2. LncRNA调控乙型脑炎病毒介导炎症反应的分子机制，国家自然科学基金，2016-2019，项目主持
3. 乙型脑炎病毒激活小胶质细胞的分子机制，国家自然科学基金，2012-2015，项目主持
4. 乙型脑炎病毒诱导炎症损伤的分子机制，教育部新世纪优秀人才支持计划，2011-2013，项目主持
5. 猪乙型脑炎高效疫苗与诊断试剂产业化，农业公益性行业专项，2012-2016，课题主持
6. II型包膜病毒的入侵机制－乙型脑炎病毒入侵机制，973，2009-2013，项目骨干
7. 猪流行性乙型脑炎综合防控技术体系研究与示范，农业公益性行业专项，2008-2010，课题主持
8. 非洲猪瘟等重要外来动物疫病综合防控技术研究，农业公益性行业专项，2009-2013，课题主持
9. 乙型脑炎病毒强弱毒株在小鼠体内增殖与分布规律研究，国家自然科学基金，2007-2009，项目主持

主要奖励

1. 2016年获湖北省科技进步一等奖，排名1
2. 2013年获湖北省第十一届青年科技奖
3. 2012年获武汉市第三届青年科技奖
4. 2007年获湖北省科技进步一等奖，排名7